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Nefazodone

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Nefazodone (sold as Serzone, Nefadar) is a psychoactive drug and antidepressant marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries due to the rare incidence of hepatotoxicity (liver damage), which could lead to the need for a liver transplant, or even death. The incidence of severe liver damage is approximately 1 in every 250,000 to 300,000 patients. On May... Read enhanced Wikipedia article

Factz from Wikipedia: we found the following about nefazodone  

caused :
failure and levels.

Results for "nefazodone caused failure"

Serotonin-norepinephrine reuptake inhibitor Currently, the risk of liver damage appears only to be for patients already at risk, unlike the discontinued antidepressant nefazodone which, though rare, can spontaneously cause liver failure in healthy patients.

Results for "nefazodone caused levels"

Diazepam Nefazodone can cause increased blood levels of benzodiazepines.

inhibited :
CYP3 A4 and isozyme.

Results for "nefazodone inhibited CYP3 A4"

Nefazodone Nefazodone is a potent inhibitor of CYP3A4, an isozyme of the cytochrome P450 system, and may therefore interact adversely with many commonly-used medications that are metabolized by CYP3A4.

Results for "nefazodone inhibited isozyme"

Nefazodone Nefazodone is a potent inhibitor of CYP3A4, an isozyme of the cytochrome P450 system, and may therefore interact adversely with many commonly-used medications that are metabolized by CYP3A4.

impaired  
metabolism.

Results for "nefazodone impaired metabolism"

Zopiclone Nefazodone impairs the metabolism of zopiclone leading to increased zopiclone levels and marked next day sedation.

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false
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Wikipedia Articles

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    Nefazodone

    Nefazodone (Serzone, Nefadar) is a psychoactive drug and antidepressant marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries due to the rare incidence of hepatotoxicity (liver damage), which could lead to the need for a liver transplant, or even death.
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    List of drugs: Nb-Nh

    A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z ... nefazodone (INN)
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    Piperazine

    Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. ... Nefazodone
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    ATC code N06

    ATC code N06 Psychoanaleptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. ... N06AX06 Nefazodone
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    List of antidepressants

    This is a list of antidepressants by drug group. ... Nefazodone (Nefadar, Serzone)
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    ATC code N05

    ATC code N05 Psycholeptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products.... ... ... • Bromodiphenhydramine • Carbinoxamine • Doxepin • Orphenadrine • Mianserin • Mirtazapine • Nefazodone • Niaprazine • Phenyltoloxamine • Propiomazine • Pyrilamine • Scopolamine • Trazodone | |
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    Midazolam

    Midazolam (pronounced /mɪˈdæzəlæm/, and marketed in English-speaking countries under brand names Dormicum, Hypnovel, and Versed) is an ultra short-acting drug in the benzodiazepine class that is used for treatment of acute seizures and for inducing sedation and amnesia before medical procedures. ... HIV protease inhibitors, nefazodone, sertraline, grapefruit juice, fluoxetine, erythromycin, diltiazem, clarithromycin inhibit the metabolism of midazolam, leading to a prolonged action.
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    Norepinephrine reuptake inhibitor

    A norepinephrine reuptake inhibitor (NRI, NERI) or adrenergic reuptake inhibitor (ARI), is a type of drug which acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET). ... Nefazodone (Serzone) (weak)
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    Triazolam

    Triazolam (marketed in English speaking countries under the brand names Apo-Triazo, Halcion, Hypam, and Trilam) is a benzodiazepine derivative drug. ... Other important interactions include cimetidine, diltiazem,erythromycin, fluconazole, grapefruit juice, isoniazid, itraconazole, ketoconazole, nefazodone, rifampicin, ritonavir, troleandomycin.
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    Zopiclone

    Zopiclone, (brand name Imovane in Canada, and Zimovane in the UK) is a non-benzodiazepine hypnotic agent used in the treatment of insomnia. ... Nefazodone impairs the metabolism of zopiclone leading to increased zopiclone levels and marked next day sedation.

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