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   Primidone

   In many cases, it was not clear which drug had caused it. ... Primidone also causes exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
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   Biotin deficiency

   Anticonvulsant therapy: Prolonged use of certain drugs, especially phenytoin, primidone, and carbamazepine, may lead to biotin deficiency; however, valproic acid therapy does not cause this condition. ... Seborrheic dermatitis

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