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Survivin

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Survivin, also called Baculoviral IAP repeat-containing 5 (BIRC5), is a human gene that is part of the inhibitor of apoptosis family (IAP). The survivin protein functions to inhibit caspase activation therefore leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in... Read enhanced Wikipedia article

Factz from Wikipedia: we found the following about survivin help

inhibited :
apoptosis, result, process, Bax, activity, cytochrome, forms and pathways.

Results for "survivin inhibited apoptosis"

Survivin As survivin is a known inhibitor of apoptosis, it can be implied that p53 repression of survivin is one mechanism in which cells can undergo apoptosis upon induction by apoptotic stimuli or signals.

Survivin "IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.".

Results for "survivin inhibited result"

Survivin While survivin has been shown as mentioned above to bind to only the active forms of these caspases, it is likely here that survivin inhibits the active forms of the caspases resulting from cleaving and activating more of its own proforms.

Results for "survivin inhibited process"

Survivin They showed that survivin inhibited processing of these two caspases into their active forms.

Results for "survivin inhibited Bax"

Survivin Tamm et al. have shown that survivin inhibits both Bax and Fas-induced apoptotic pathways.

Results for "survivin inhibited activity"

Survivin "IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.".

Results for "survivin inhibited cytochrome"

Survivin Although the details are not here, survivin was shown to also inhibit cytochrome c and caspase-8 induced activation of caspases.

Results for "survivin inhibited forms"

Survivin While survivin has been shown as mentioned above to bind to only the active forms of these caspases, it is likely here that survivin inhibits the active forms of the caspases resulting from cleaving and activating more of its own proforms.

Results for "survivin inhibited pathways"

Survivin Tamm et al. have shown that survivin inhibits both Bax and Fas-induced apoptotic pathways.

showed :
phenotype and localize.

Results for "survivin showed phenotype"

Centromere protein E "Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.".

CENPA "Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.".

Results for "survivin showed localize"

Centromere protein E "Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.".

CENPA "Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.".

bind to :
caspases and forms.

Results for "survivin bind to caspases"

Survivin Survivin also does not bind to active caspase-8.

Survivin While survivin has been shown as mentioned above to bind to only the active forms of these caspases, it is likely here that survivin inhibits the active forms of the caspases resulting from cleaving and activating more of its own proforms.

Results for "survivin bind to forms"

Survivin While survivin has been shown as mentioned above to bind to only the active forms of these caspases, it is likely here that survivin inhibits the active forms of the caspases resulting from cleaving and activating more of its own proforms.

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Wikipedia Articles: results 1 - 10 of 31
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    Survivin

    Survivin, also called Baculoviral IAP repeat-containing 5 (BIRC5), is a human gene that is part of the inhibitor of apoptosis family (IAP). The survivin protein functions to inhibit caspase activation therefore leading to negative regulation of apoptosis or programmed cell death.
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    André Cymone

    The two later resolved their issues and Cymone went on to release 3 solo albums — Livin' in the New Wave (1982), Survivin' in the 80's (1983), and AC (1985).
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    EPR1

    "Downregulation of survivin expression by induction of the effector cell protease receptor-1 reduces tumor growth potential and results in an increased sensitivity to anticancer agents in human colon cancer.".
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    BIRC7

    "Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer.".
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    CDCA8

    "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.".
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    Aurora B kinase

    "Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.".
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    INCENP

    "Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.".
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    XPO1

    "Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential.".
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    The Gambler (song)

    The gambler then mentions that the "secret to survivin' is knowing what to throw away and knowing what to keep" and that "the best you can hope for is to die in your sleep".
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    USP10

    "Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM).".
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