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   Epigenetics

   Several types of epigenetic inheritance systems may play a role in what has become known as cell memory: ... Some investigators, like Randy Jirtle, PhD, of Duke University Medical Center, think epigenetics may ultimately turn out to have a greater role in disease than genetics.
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   Illumina Methylation Assay

   The Illumina Methylation Assay using the Infinium II platform uses "BeadChip" technology to generate a comprehensive genome wide profiling of human DNA methylation. ... A large scale measurement of DNA methylation patterns from a wide selection of genes may enable us to understand better the relationships between epigenetic changes and the genesis of different diseases and a better understanding of the role that epigenetic plays in tissue specific differentiation.
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   Computational epigenetics

   Computational epigenetics uses bioinformatic methods to complement experimental research in epigenetics. Due to the recent explosion of epigenome datasets, computational methods play an increasing role in all areas of epigenetic research.
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   Methyllysine

   In proteins, the amino acid residue lysine can be methylated once, twice or thrice on its terminal sidechain ammonium group. Such methylated lysines play an important role in epigenetics; the methylation of specific lysines of certain histones in a nucleosome alters the binding of the surrounding DNA to those histones, which in turn effects the expression of genes on that DNA.
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   Epigenetic principle

   The epigenetic principle is an idea developed by Erik Erikson that states that every organism is born with a certain purpose, and continues to develop how it was intended to in interrelation with its environment. Biology unfolding in relation to a socio-cultural setting.
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   Dihydropyrimidine dehydrogenase deficiency

   Dihydropyrimidine dehydrogenase deficiency (DPD deficiency) is an autosomal recessive metabolic disorder in which there is absent or significantly decreased activity of dihydropyrimidine dehydrogenase, an enzyme involved in the metabolism of uracil and thymine. ... The whole genetic events affecting the DPYD gene and possibly impacting on its function are far from being elucidated, and epigenetic regulations could probably play a major role in DPD deficiency.
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   WIF1

   Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. ... [Expression error: Missing operand for > "Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway."].
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   CHD4

   Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. ... It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression.
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   The Real Superhumans

   The Real Superhumans and the Quest for the Future Fantastic is a two hour long special from the Discovery Channel which aired in 2007. ... However, many scientists now dispute this orthodoxy, as there are sufficient scientific grounds to think that genetics has limited scope in explaining all human characteristics, and epigenetic processes play a much larger role than previously realised.
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    Survivin

    Epigenetic and genetic regulation ... To further see whether survivin played a key role in sensitization of the cancer cells to cytotoxic drugs, survivin antisense oligonucleotides were used to knock down any survivin mRNA and thus its possibility to be translated is also eliminated. siRNAs for survivin are basically complements in sequence to the mRNA sequence encoding survivin.

Explore the following pages on Powerset:

• Epigenetics,
• Illumina Methylation Assay,
• Computational epigenetics,
• Methyllysine,
• Epigenetic principle,
• Dihydropyrimidine dehydrogenase deficiency,
• WIF1,
• CHD4,
• The Real Superhumans,
• Survivin

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