Finding:

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   Gene silencing

   Gene silencing is a general term describing epigenetic processes of gene regulation. ... Genes may be silenced by DNA methylation during meiosis, as in the filamentous fungus Neurospora crassa.
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   Epigenetics

   Thus, as individuals develop, morphogens activate or silence genes in an epigenetically heritable fashion, giving cells a "memory". ... "Epigenetic Regulation of Gene Expression".
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   Microsatellite instability

   Microsatellites are repeated sequences of DNA. ... The second mechanism whereby MSI causes colorectal cancer is an epigenetic change that silences an essential mismatch-repair gene.
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   Gene expression

   Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. ... | epigenetic regulation (Genomic imprinting) |
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   Regulation of gene expression

   Regulation of gene expression (or gene regulation) includes the processes that cells and viruses use to turn the information in genes into gene products. ... Main article: Epigenetic regulation
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   Genomic imprinting

   Genomic imprinting is an epigenetic process that involves methylation and histone modifications in order to achieve monoallelic gene expression without altering the genetic sequence. ... A hypothesis for the origin of this genetic variation states that the host-defense system responsible for silencing foreign DNA elements, such as genes of viral origin, mistakenly silenced genes whose silencing turned out to be beneficial for the organism.
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   David Baulcombe

   "Potato virus X amplicons in arabidopsis mediate genetic and epigenetic gene silencing" (Free full text). ... Candidate 'gene silencers' found"].
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   Methylated DNA immunoprecipitation

   Alternatively, one can identify genes that are known to be normally methylated but, as a result of some mutation event, is no longer silenced. ... "Epigenetic inactivation of the HOXA gene cluster in breast cancer".
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   Long noncoding RNA

   Long ncRNAs in gene-specific transcription ... For example, the majority of protein-coding genes have antisense partners, including many tumour suppressor genes that are frequently silenced by epigenetic mechanisms in cancer (Yu 2008).
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    Methylation

    In the chemical sciences, methylation denotes the addition of a methyl group to a substrate or the substitution of an atom or group by a methyl group. ... In cancer, the dynamics of genetic and epigenetic gene silencing are very different.

Explore the following pages on Powerset:

• Gene silencing,
• Epigenetics,
• Microsatellite instability,
• Gene expression,
• Regulation of gene expression,
• Genomic imprinting,
• David Baulcombe,
• Methylated DNA immunoprecipitation,
• Long noncoding RNA,
• Methylation

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