Finding:

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   Computational epigenetics

   Computational epigenetics uses bioinformatic methods to complement experimental research in epigenetics. ... Various experimental techniques have been developed for genome-wide mapping of epigenetic information, the most widely used being ChIP-on-chip, ChIP-seq and bisulfite sequencing.
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   Epigenetics

   Furthermore, the use of bioinformatic methods is playing an increasing role (computational epigenetics). ... Several types of epigenetic inheritance systems may play a role in what has become known as cell memory:
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   Bisulfite sequencing

   DNA methylation was the first discovered epigenetic mark, and remains the most studied. ... Fluorescence-based methods or Pyrosequencing can also be used.
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   Axel Schumacher

   Dr. Schumacher is the co-inventor of so called high-throughput "epigenetic microarrays," used for the analysis of epigenetic regulation of human genes.
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   Reelin

   There are conflicting data concerning the importance of this layer, and these are explained in the literature either by the existence of an additional signaling positional mechanism that interacts with the reelin cascade, or by the assumption that mice that are used in such experiments have redundant secretion of reelin compared with more localized synthesis in the human brain. ... "On the epigenetic regulation of the human reelin promoter".
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   Survivin

   The X-ray film was quantified by scanning densitometry using the IS-1000 imaging system. ... This is explained below in the epigenetic regulation section.
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   Somatic evolution in cancer

   Traditionally, many of the somatic evolutionary studies have been focused on clonal expansion, as recurrent types of changes can be traced to illustrate the evolutionary path based on available methods. ... Epigenetic changes in progression interact with genetic changes.
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   Secreted frizzled-related protein 1

   Lithium chloride is widely used to mimic Wnt signaling. ... "Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer".
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   Nucleic acid methods

   Nucleic acid methods are the techniques used to study nucleic acids (DNA and RNA). ... Epigenetic · genetic · post-transcriptional · post-translational regulation
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    DNA sequencing

    Also sometimes known as 'chemical sequencing', this method originated in the study of DNA-protein interactions (footprinting), nucleic acid structure and epigenetic modifications to DNA, and within these it still has important applications. ... The different strategies have different tradeoffs in speed and accuracy; shotgun methods are often used for sequencing large genomes, but its assembly is complex and difficult, particularly with sequence repeats often causing gaps in genome assembly.

Explore the following pages on Powerset:

• Computational epigenetics,
• Epigenetics,
• Bisulfite sequencing,
• Axel Schumacher,
• Reelin,
• Survivin,
• Somatic evolution in cancer,
• Secreted frizzled-related protein 1,
• Nucleic acid methods,
• DNA sequencing